Brodie abscess pathophysiology

Local trauma and bacteremia lead to increased susceptibility to bacterial seeding of the metaphysis. History of trauma is reported in 30% of patients.

• Local trauma and bacteremia lead to increased susceptibility to bacterial seeding of the metaphysis. History of trauma is reported in 30% of patients. Brodie abscess arises where the bacteria and the host defenses are equally balanced. Bacteria proliferate in bone and cause inflammation and necrosis. It spreads through the haversian system or medullary cavity within the shaft and to periosteum. To reduce the systemic response, the abscess is walled-off. An osseous infection can be caused by hematogenous spread of pathogens to bone or by direct inoculations by bacteria. The organisms reach the bone from a disrupted site else where in the body such as a skin pustule, furuncles, impetigo, infected blisters and burns, or secondary to an infection of another organ system (urogenital infections, enteritis, cholangitis or endocarditis. ^[1]

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