Brucellosis history and symptoms

• Undulant fever
  • High fever spikes usually occur every afternoon
• Night sweats
  • Often with characteristic smell, likened to wet hay
• Chills
• Fatigue
• Loss of appetite
• Weakness
• Weight loss

• Depression

Focal organ wise symptoms:

• Muscuoskeletal: Joint pain(Commonly in low back and larger joints of lower limbs)
• Genitourinary: Pain in the genital region and increase in frequency of urination/burning senation while passing urine(2 to 20 percent of cases)
• Pulmonary: Cough, chest pain, difficulty in breathing(pulmonary involvement present upto 7 percent of patients)
• Gastrointestinal: Abdominal pain and symptoms of hepatitis can be present in 3-6 percent of presenting patients
• Neurological: Headache, confusion or altered sensorium (meningoencephalitits), loss of sensation (radiculopathies or neuritis involving the cranial or peripheral nerves) can be present in 2-7 percent of patients
• Cardiovascular: Chest pain is rare cardiovascular feature of brucellosis
• Ocular: Difficulty in vision and dimenision of vision
• Dermatology: Rash, ulcer or tender swelling can present with brucellosis upto 10 percent of patients

• Relapse occurs in 5 to 15 percent of patient usually in first 6 months following treatment, although in rare cases it may even occur in up to 12 months of treatment.^[13][14]
• General well-being and changes in body weight help in diagnosis of relapse.

Clinical manifestations include:^{[15] [16]}

• Fatigue
• Arthralgia
• Malaise
• Myalgia
• Uveitis: patients complains of difficulty of vision
• Spondylitis, osteomyelitis, Arthralgias: patients complains of pain in joints or joint movement
• Intermittent sweating