Brugada syndrome drugs to avoid

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

There are certain drugs that should be avoided in patients with Brugada syndrome. These drugs include ajmaline, flecainide, pilsicainide, procainamide, and propafenone. These drugs are all sodium blocking antiarrhythmics which are either in the IA class or IC class.

Drugs to Avoid

The following drugs should be avoided in patients with Brugada syndrome. ^[1]^[2]

Generic name	Brand name®	Class / Clinical use	References	Recommendation
Ajmaline	e.g. Gilurytmal® – more brand names here –	Antiarrhythmic Agent (1A: Na-blocker) / Arrhythmias	Brugada 1997 Rolf 2003 Wolpert 2005 Bébarová 2005	Class I
Flecainide	e.g. Tambocor® – more brand names here –	Antiarrhythmic Agent (1C: Na-blocker) / Arrhythmias	Krishnan 1998 Brugada 2000 Gasparini 2003 Meregalli 2006 Stokoe 2007	Class I
Pilsicainide	e.g. Sunrhythm® – more brand names here –	Antiarrhythmic Agent (1C: Na-blocker) / Arrhythmias	Takenaka 1999 Fujiki 1999 Takagi 2002 Kimura 2004	Class I
Procainamide	e.g. Procan® Pronestyl® – more brand names here –	Antiarrhythmic Agent (1A: Na-blocker) / Arrhythmias	Miyazaki 1996 Brugada 1997 Joshi 2007 Villemaire 1992	Class I
Propafenone	e.g. Rythmol® – more brand names here –	Antiarrhythmic Agent (1C: Na-blocker) / Arrhythmias	Matana 2000 Akdemir 2002 Hasdemir 2006 Shan 2008 Stark 1996	Class IIa

Recommendation: Class I: convincing evidence/opinion; Class IIa: evidence/opinion less clear; Class IIb: conflicting evidence/opinion; Class III: very little evidence.

References

↑ www.brugadadrugs.org
↑ Postema PG, Wolpert C, Amin AS, Probst V, Borggrefe M, Roden DM, Priori SG, Tan HL, Hiraoka M, Brugada J, Wilde AA (2009). “Drugs and Brugada syndrome patients: review of the literature, recommendations, and an up-to-date website (www.brugadadrugs.org)”. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 6 (9): 1335–41. doi:10.1016/j.hrthm.2009.07.002. PMC 2779019. PMID 19716089. Retrieved 2012-10-13. Unknown parameter |month= ignored (help)

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[1] www.brugadadrugs.org

[pmid19716089-2] Postema PG, Wolpert C, Amin AS, Probst V, Borggrefe M, Roden DM, Priori SG, Tan HL, Hiraoka M, Brugada J, Wilde AA (2009). “Drugs and Brugada syndrome patients: review of the literature, recommendations, and an up-to-date website (www.brugadadrugs.org)”. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 6 (9): 1335–41. doi:10.1016/j.hrthm.2009.07.002. PMC 2779019. PMID 19716089. Retrieved 2012-10-13. Unknown parameter |month= ignored (help)

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Brugada syndrome drugs to avoid

Overview

Drugs to Avoid

References

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