Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
C4 glomerulopathy classification
Introduction
Overview
Overview
C4 glomerulopathy may be classified based on complement deposition into dense deposit disease and C4 glomerulonephritis.
Classification
Classification
- C4 glomerulopathy is categorized as a variant of MPGN[1][2].
- Recently, Sethi et al. have defined a new term “C4d glomerulopathy”
- C4 Glomerulopathy may be classified into 2 main subtypes based on the appearance of complement deposition in the glomerular basement membrane on electron microscopy:
- Dense deposit disease (DDD)
- Presence of C4 granular or osmiophilic deposition along the basement membrane on immunofluorescence or immunohistochemistry.
- C4 Glomerulonephritis (C4GN)
- Isolated deposition of C4.
- Dense deposit disease (DDD)
References
References
- ↑ Ali A, Schlanger L, Nasr SH, Sethi S, Gorbatkin SM (2016). “Proliferative C4 Dense Deposit Disease, Acute Thrombotic Microangiopathy, a Monoclonal Gammopathy, and Acute Kidney Failure”. Am J Kidney Dis. 67 (3): 479–82. doi:10.1053/j.ajkd.2015.10.020. PMID 26704376.
- ↑ Sethi S, Sullivan A, Smith RJ (2014). “C4 dense-deposit disease”. N Engl J Med. 370 (8): 784–6. doi:10.1056/NEJMc1309449. PMID 24552345.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Ali Poyan Mehr, M.D. [2]; Associate Editor(s)-in-Chief: Olufunmilola Olubukola M.D.[3]