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C5orf3
Introduction
C5orf3 (chromosome 5 open reading frame 3) is a gene on chromosome 5 in humans that encodes a protein FAM114A2. This protein has a function that is not well known. C5orf3 is, however, highly conserved in mammals with homologs both in fungi and plants.
| Species | Accession # | Identity |
|---|---|---|
| macaca mulatta | XM_001102467 | 78.1% |
| Pan troglodytes | XM_518045 | 89.7% |
| bos taurus | NP_001033166 | 85.6% |
| Pongo abelii | XM_002816109 | 87.8% |
| Mus musculus | NM_026342.3 | 79% |
| Callithrix jacchus | XP_002744467 | 94.7% |
Protein
Protein
The c5orf3 protein is 505 amino acids long[1] with a molecular weight of 55.5 kdal and an isoelectric point of 4.66.[2] It is predicted to stay in the nucleus after translation [3] There is evidence that c5orf3 interacts with another protein of unknown function from chromosome 5, c5orf4 [4] This protein is thought to include a P loop [5] that suggests a role in ATP– and/or GTP-binding [6]
Gene
Gene
The c5orf3 gene is located on chromosome 5 (5q31-33).[7] This gene has 14 exons spanning through its sequence.[1] The coding sequence is 2886 base pairs with a 5’ UTR of 94 base pairs and a 3’ UTR of 1273 base pairs.[1] It is expressed at high levels in most tissues of the human body.[7] It is also highly expressed in tissues in the human brain [8]
References
References
- ↑ 1.0 1.1 1.2 Homo sapiens family with sequence similarity 114, member A2 (FAM114A2) – Nucleotide – NCBI
- ↑ Biology workbench: http://seqtool.sdsc.edu/CGI/BW.cgi#!
- ↑ PSORT WWW Server
- ↑ STRING: http://string-db.org/newstring_cgi/show_network_section.pl.
- ↑ http://string-db.org/newstring_cgi/show_textmining_evidence.pl.
- ↑ Saraste M, Sibbald PR, Wittinghofer A (November 1990). “The P-loop–a common motif in ATP- and GTP-binding proteins”. Trends Biochem. Sci. 15 (11): 430–4. doi:10.1016/0968-0004(90)90281-f. PMID 2126155.
- ↑ 7.0 7.1 FAM114A2 Gene – GeneCards | F1142 Protein | F1142 Antibody
- ↑ Allen Brain Atlas: http://human.brain-map.org/search?type=mi
.
External links
External links
- Human FAM114A2 genome location and FAM114A2 gene details page in the UCSC Genome Browser.
Further reading
Further reading
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). “Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes”. Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). “Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library”. Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Maruyama K, Sugano S (1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.