Health Dictionary
Reliable, easy-to-read patient information on common medical conditions β written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
CACNA2D1
Introduction
Voltage-dependent calcium channel subunit alpha-2/delta-1 is a protein that in humans is encoded by the CACNA2D1 gene.[1][2]
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[2]
Gabapentinoids
Gabapentinoids
alpha2/delta proteins are believed to be the molecular target of the gabapentinoids gabapentin and pregabalin, which are used to treat epilepsy and neuropathic pain.[3][4][5]
References
References
- β Powers PA, Scherer SW, Tsui LC, Gregg RG, Hogan K (Jun 1994). “Localization of the gene encoding the alpha 2/delta subunit (CACNL2A) of the human skeletal muscle voltage-dependent Ca2+ channel to chromosome 7q21-q22 by somatic cell hybrid analysis”. Genomics. 19 (1): 192β3. doi:10.1006/geno.1994.1044. PMIDΒ 8188232.
- β 2.0 2.1 “Entrez Gene: CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1”.
- β Rogawski MA, Bazil CW (July 2008). “New molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channels”. Curr Neurol Neurosci Rep. 8 (4): 345β52. doi:10.1007/s11910-008-0053-7. PMCΒ 2587091. PMIDΒ 18590620.
- β Patel, Ryan; Dickenson, Anthony H. (2016-04-01). “Mechanisms of the gabapentinoids andΞ±2Ξ΄-1 calcium channel subunit in neuropathic pain”. Pharmacology Research & Perspectives. 4 (2). doi:10.1002/prp2.205. ISSNΒ 2052-1707.
- β Patel, Ryan; Bauer, Claudia S.; Nieto-Rostro, Manuela; Margas, Wojciech; Ferron, Laurent; Chaggar, Kanchan; Crews, Kasumi; Ramirez, Juan D.; Bennett, David L. H. (2013-10-16). “Ξ±2Ξ΄-1 Gene Deletion Affects Somatosensory Neuron Function and Delays Mechanical Hypersensitivity in Response to Peripheral Nerve Damage”. Journal of Neuroscience. 33 (42): 16412β16426. doi:10.1523/jneurosci.1026-13.2013. PMCΒ 3797367.
Further reading
Further reading
- Williams ME, Feldman DH, McCue AF, et al. (1992). “Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype”. Neuron. 8 (1): 71β84. doi:10.1016/0896-6273(92)90109-Q. PMIDΒ 1309651.
- Ellis SB, Williams ME, Ways NR, et al. (1988). “Sequence and expression of mRNAs encoding the alpha 1 and alpha 2 subunits of a DHP-sensitive calcium channel”. Science. 241 (4873): 1661β4. doi:10.1126/science.2458626. PMIDΒ 2458626.
- Iles DE, Lehmann-Horn F, Scherer SW, et al. (1994). “Localization of the gene encoding the alpha 2/delta-subunits of the L-type voltage-dependent calcium channel to chromosome 7q and analysis of the segregation of flanking markers in malignant hyperthermia susceptible families”. Hum. Mol. Genet. 3 (6): 969β75. doi:10.1093/hmg/3.6.969. PMIDΒ 7951247.
- Brust PF, Simerson S, McCue AF, et al. (1994). “Human neuronal voltage-dependent calcium channels: studies on subunit structure and role in channel assembly”. Neuropharmacology. 32 (11): 1089β102. doi:10.1016/0028-3908(93)90004-M. PMIDΒ 8107964.
- “Toward a complete human genome sequence”. Genome Res. 8 (11): 1097β108. 1999. doi:10.1101/gr.8.11.1097. PMIDΒ 9847074.
- Schleithoff L, Mehrke G, Reutlinger B, Lehmann-Horn F (1999). “Genomic structure and functional expression of a human alpha(2)/delta calcium channel subunit gene (CACNA2)”. Genomics. 61 (2): 201β9. doi:10.1006/geno.1999.5941. PMIDΒ 10534405.
- Bell DC, Butcher AJ, Berrow NS, et al. (2001). “Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents”. J. Neurophysiol. 85 (2): 816β27. PMIDΒ 11160515.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899β903. doi:10.1073/pnas.242603899. PMCΒ 139241. PMIDΒ 12477932.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). “The DNA sequence of human chromosome 7”. Nature. 424 (6945): 157β64. doi:10.1038/nature01782. PMIDΒ 12853948.
- Stotz SC, Barr W, McRory JE, et al. (2004). “Several structural domains contribute to the regulation of N-type calcium channel inactivation by the beta 3 subunit”. J. Biol. Chem. 279 (5): 3793β800. doi:10.1074/jbc.M308991200. PMIDΒ 14602720.
- Liu T, Qian WJ, Gritsenko MA, et al. (2006). “Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry”. J. Proteome Res. 4 (6): 2070β80. doi:10.1021/pr0502065. PMCΒ 1850943. PMIDΒ 16335952.
- Antzelevitch C, Pollevick GD, Cordeiro JM, et al. (2007). “Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death”. Circulation. 115 (4): 442β9. doi:10.1161/CIRCULATIONAHA.106.668392. PMCΒ 1952683. PMIDΒ 17224476.
- Chaudhuri D, Issa JB, Yue DT (2007). “Elementary mechanisms producing facilitation of Cav2.1 (P/Q-type) channels”. J. Gen. Physiol. 129 (5): 385β401. doi:10.1085/jgp.200709749. PMCΒ 2154375. PMIDΒ 17438119.
External links
External links
- CACNA2D1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CACNA2D1 genome location and CACNA2D1 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.