Health Dictionary
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CAMP response element modulator
Introduction
{{free media}}“cAMP-response-element modulator (CREM), a transcription factor responsive to the cAMP signal transduction pathway, drives expression of key testis-specific genes.”[1]
“Transcription factors of the cAMP-response-element binding protein (CREB)–CREM family target genes with cAMP response elements (CREs) constituted by the palindromic consensus sequence TGACGTCA (Sassone-Corsi et al. 1988).”[1]
“Within the activation domain is the P-(phosphorylation) box containing the target residue for PKA phosphorylation, among other phosphoacceptor sites.”[1]
References
References
- ↑ 1.0 1.1 1.2 Sarah Kimmins, Noora Kotaja, Irwin Davidson and Paolo Sassone-Corsi (1 July 2004). “Testis-specific transcription mechanisms promoting male germ-cell differentiation”. Reproduction. 128 (1): 5–12. doi:10.1530/rep.1.00170. Retrieved 2017-02-19.