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CCDC90B

Introduction

Coiled coil domain containing 90B, also known as CCDC90B, is a protein encoded by the CCDC90B gene.

Gene

Gene

CCDC90B is located on chromosome 11 in humans. It is neighbored by:[1]

  • PCF11, a mammalian pre-mRNA cleavage complex 2 protein
  • ANKRD42, ankyrin repeat protein involved with calcium ion bonding
  • BC070093
  • DLG2, a member of the membrane-associated guanylate kinase (MAGUK) family
Protein

Protein

Structure

This protein is characterized by the presence of a domain of unknown function, DUF1640. This domain is a characteristic of the entire protein with the exception of the first twenty-three amino acid residues – MNSRQAWRLFLSQGRGDRWVSRP – which are a mitochondrial targeting site and cleaved.

The protein has seven predicted alpha helices, a characteristic of coiled-coil proteins.

Predicted Properties

Molecular Weight: 26.72 kDa

Isoelectric point: 7.5

Transmembrane Helices: None

Post-translation modifications:[2]

Chloroplast transit peptides: None
Signal pepties: None
C-mannosylation sites: None
N-glycosylation sites: None
Mitochondrial targeting: Yes
Cleaved site: MNSRQAWRLFLSQGRGDRWVSRP

Cellular Location

CCDC90B is presumably a mitochondrial protein. It is predicted to contain at least three specific phosphorylation sites: Protein Kinase C Phosphorylation sites, Casein Kinase II Phosphorylation sites, and cAMP/cGMP Dependant Phosphorylation sites.

References

References

  1. ↑ “UCSC Genome Bioinformatics BLAT”. University of California – Santa Cruz. March 2006. Retrieved 2009-05-14.
  2. ↑ “ExPASy”. SIB Switzerland. 2009-01-05. Retrieved 2009-05-14.
External links