Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
CCL1
Introduction
Chemokine (C-C motif) ligand 1 (CCL1) is a small glycoprotein secreted by activated T cells that belongs to a family of inflammatory cytokines known as chemokines.[1] CCL1 attracts monocytes, NK cells, and immature B cells and dendritic cells by interacting with a cell surface chemokine receptor called CCR8.[2] This chemokine resides in a large cluster of CC chemokines on human chromosome 17.
References
- ↑ Miller MD, Krangel MS (April 1992). “The human cytokine I-309 is a monocyte chemoattractant”. Proc. Natl. Acad. Sci. U.S.A. 89 (7): 2950–4. doi:10.1073/pnas.89.7.2950. PMC 48781. PMID 1557400.
- ↑ Roos RS, Loetscher M, Legler DF, Clark-Lewis I, Baggiolini M, Moser B (July 1997). “Identification of CCR8, the receptor for the human CC chemokine I-309”. J. Biol. Chem. 272 (28): 17251–4. doi:10.1074/jbc.272.28.17251. PMID 9211859.