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CD120

Introduction

CD120 (Cluster of Differentiation 120) can refer to two members of the tumor necrosis factor receptor superfamily: tumor necrosis factor receptor 1 (TNFR1) and tumor necrosis factor receptor 2 (TNFR2).[1][2]

Receptor subtypes

Receptor subtypes

There are two variants of the receptor, each encoded by a separate gene:

  • CD120a – TNFR1 – TNFR superfamily member 1A
  • CD120b – TNFR2 – TNFR superfamily member 1B

TNFR1 is the receptor type responsible for mediation of TNF-alpha induced sickness behavior,[3] and is involved in neurotoxic processes.[4] Elevated levels of TNFR1 has been found in severe mental disorders.[5]

Signaling pathway

Signaling pathway

Signaling pathway of TNF-R1. Dashed grey lines represent multiple steps
See also

See also

References

References

  1. ↑ Locksley RM, Killeen N, Lenardo MJ (2001). “The TNF and TNF receptor superfamilies: integrating mammalian biology”. Cell. 104 (4): 487–501. doi:10.1016/S0092-8674(01)00237-9. PMID 11239407.
  2. ↑ Hehlgans T, Pfeffer K (2005). “The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games”. Immunology. 115 (1): 1–20. doi:10.1111/j.1365-2567.2005.02143.x. PMC 1782125. PMID 15819693.
  3. ↑ Palin K, Bluthé RM, McCusker RH, Levade T, Moos F, Dantzer R, Kelley KW (January 2009). “The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behavior”. Psychopharmacology. 201 (4): 549–56. doi:10.1007/s00213-008-1331-4. PMC 2711641. PMID 18825372.
  4. ↑ McCoy MK, Tansey MG (2008). “TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease”. J Neuroinflammation. 5 (1): 45. doi:10.1186/1742-2094-5-45. PMC 2577641. PMID 18925972.
  5. ↑ Hope S, Melle I, Aukrust P, Steen NE, Birkenaes AB, Lorentzen S, Agartz I, Ueland T, Andreassen OA (November 2009). “Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor”. Bipolar Disord. 11 (7): 726–34. doi:10.1111/j.1399-5618.2009.00757.x. PMID 19839997.
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