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Reliable, easy-to-read patient information on common medical conditions β€” written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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CD27

Introduction

CD27 is a member of the tumor necrosis factor receptor superfamily. It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule.

Function

Function

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-ΞΊB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.[1]

Clinical significance

Clinical significance

As a drug target

Varlilumab is an antibody that binds to CD27 and is an experimental cancer treatment.

Interactions

Interactions

CD27 has been shown to interact with SIVA1,[2] TRAF2[3][4] and TRAF3.[3][4]

References

References

  1. ↑ “Entrez Gene: CD27 CD27 molecule”.
  2. ↑ Prasad KV, Ao Z, Yoon Y, Wu MX, Rizk M, Jacquot S, Schlossman SF (Jun 1997). “CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein”. Proceedings of the National Academy of Sciences of the United States of America. 94 (12): 6346–51. doi:10.1073/pnas.94.12.6346. PMCΒ 21052. PMIDΒ 9177220.
  3. ↑ 3.0 3.1 Yamamoto H, Kishimoto T, Minamoto S (Nov 1998). “NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of CD27”. Journal of Immunology. 161 (9): 4753–9. PMIDΒ 9794406.
  4. ↑ 4.0 4.1 Akiba H, Nakano H, Nishinaka S, Shindo M, Kobata T, Atsuta M, Morimoto C, Ware CF, Malinin NL, Wallach D, Yagita H, Okumura K (May 1998). “CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase”. The Journal of Biological Chemistry. 273 (21): 13353–8. doi:10.1074/jbc.273.21.13353. PMIDΒ 9582383.
Further reading

Further reading

  • Lens SM, de Jong R, Hintzen RQ, Koopman G, van Lier RA, van Oers RH (Jun 1995). “CD27-CD70 interaction: unravelling its implication in normal and neoplastic B-cell growth”. Leukemia & Lymphoma. 18 (1–2): 51–9. doi:10.3109/10428199509064922. PMIDΒ 8580829.
  • Agematsu K (Apr 2000). “Memory B cells and CD27”. Histology and Histopathology. 15 (2): 573–6. PMIDΒ 10809378.
  • van Baarle D, Kostense S, van Oers MH, Hamann D, Miedema F (Dec 2002). “Failing immune control as a result of impaired CD8+ T-cell maturation: CD27 might provide a clue”. Trends in Immunology. 23 (12): 586–91. doi:10.1016/S1471-4906(02)02326-8. PMIDΒ 12464570.
  • DΓΆrner T, Lipsky PE (2005). “Correlation of circulating CD27high plasma cells and disease activity in systemic lupus erythematosus”. Lupus. 13 (5): 283–9. doi:10.1191/0961203304lu1014oa. PMIDΒ 15230280.
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