Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
CDH17
Introduction
Cadherin-17 is a protein that in humans is encoded by the CDH17 gene.[1][2][3]
This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine.[3]
References
References
- ↑ Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (Aug 1998). “Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity”. Genomics. 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.
- ↑ Chalmers IJ, Hofler H, Atkinson MJ (Jun 1999). “Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma”. Genomics. 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097.
- ↑ 3.0 3.1 “Entrez Gene: CDH17 cadherin 17, LI cadherin (liver-intestine)”.
Further reading
Further reading
- Gessner R, Tauber R (2001). “Intestinal cell adhesion molecules. Liver-intestine cadherin”. Ann. N. Y. Acad. Sci. 915: 136–43. doi:10.1111/j.1749-6632.2000.tb05236.x. PMID 11193569.
- Gilston A (1978). “Reducing the hazard of disconnected tubes”. Anaesthesia. 32 (9): 922. doi:10.1111/j.1365-2044.1977.tb10133.x. PMIDÂ 603017.
- Dantzig AH, Hoskins JA, Tabas LB, et al. (1994). “Association of intestinal peptide transport with a protein related to the cadherin superfamily”. Science. 264 (5157): 430–3. doi:10.1126/science.8153632. PMID 8153632.
- Suzuki Y, Tsunoda T, Sese J, et al. (2001). “Identification and characterization of the potential promoter regions of 1031 kinds of human genes”. Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC 311086. PMID 11337467.
- Grötzinger C, Kneifel J, Patschan D, et al. (2001). “LI-cadherin: a marker of gastric metaplasia and neoplasia”. Gut. 49 (1): 73–81. doi:10.1136/gut.49.1.73. PMC 1728355. PMID 11413113.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Takamura M, Sakamoto M, Ino Y, et al. (2003). “Expression of liver-intestine cadherin and its possible interaction with galectin-3 in ductal adenocarcinoma of the pancreas”. Cancer Sci. 94 (5): 425–30. doi:10.1111/j.1349-7006.2003.tb01459.x. PMID 12824888.
- Wendeler MW, Praus M, Jung R, et al. (2004). “Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin”. Exp. Cell Res. 294 (2): 345–55. doi:10.1016/j.yexcr.2003.11.022. PMID 15023525.
- Ko S, Chu KM, Luk JM, et al. (2004). “Overexpression of LI-cadherin in gastric cancer is associated with lymph node metastasis”. Biochem. Biophys. Res. Commun. 319 (2): 562–8. doi:10.1016/j.bbrc.2004.04.197. PMID 15178443.
- Takamura M, Ichida T, Matsuda Y, et al. (2004). “Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma”. Cancer Lett. 212 (2): 253–9. doi:10.1016/j.canlet.2004.03.016. PMID 15279905.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). “Large-scale characterization of HeLa cell nuclear phosphoproteins”. Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Wang XQ, Luk JM, Leung PP, et al. (2005). “Alternative mRNA splicing of liver intestine-cadherin in hepatocellular carcinoma”. Clin. Cancer Res. 11 (2 Pt 1): 483–9. PMID 15701831.
- Wang XQ, Luk JM, Garcia-Barcelo M, et al. (2007). “Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma”. Clin. Cancer Res. 12 (17): 5248–52. doi:10.1158/1078-0432.CCR-06-0558. PMID 16951245.
External links
External links
- CDH17 human gene location in the UCSC Genome Browser.
- CDH17 human gene details in the UCSC Genome Browser.
- Human CDH16 genome location and CDH16 gene details page in the UCSC Genome Browser.