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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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CLEC11A

Introduction

C-type lectin domain family 11 member A is a protein that in humans is encoded by the CLEC11A gene.[1][2][3]

Function

Function

This gene encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described but its biological nature has not been determined.[3]

References

References

  1. ↑ Hiraoka A, Sugimura A, Seki T, Nagasawa T, Ohta N, Shimonishi M, Hagiya M, Shimizu S (July 1997). “Cloning, expression, and characterization of a cDNA encoding a novel human growth factor for primitive hematopoietic progenitor cells”. Proceedings of the National Academy of Sciences of the United States of America. 94 (14): 7577–82. doi:10.1073/pnas.94.14.7577. PMC 23864. PMID 9207134.
  2. ↑ Bannwarth S, Giordanengo V, Lesimple J, Lefebvre JC (January 1998). “Molecular cloning of a new secreted sulfated mucin-like protein with a C-type lectin domain that is expressed in lymphoblastic cells”. The Journal of Biological Chemistry. 273 (4): 1911–6. doi:10.1074/jbc.273.4.1911. PMID 9442024.
  3. ↑ 3.0 3.1 “Entrez Gene: CLEC11A C-type lectin domain family 11, member A”.
Further reading

Further reading

  • Hiraoka A, Ohkubo T, Fukuda M (October 1987). “Production of human hematopoietic survival and growth factor by a myeloid leukemia cell line (KPB-M15) and placenta as detected by a monoclonal antibody”. Cancer Research. 47 (19): 5025–30. PMID 3304620.
  • Mio H, Kagami N, Yokokawa S, Kawai H, Nakagawa S, Takeuchi K, Sekine S, Hiraoka A (August 1998). “Isolation and characterization of a cDNA for human mouse, and rat full-length stem cell growth factor, a new member of C-type lectin superfamily”. Biochemical and Biophysical Research Communications. 249 (1): 124–30. doi:10.1006/bbrc.1998.9073. PMID 9705843.
  • Bannwarth S, Giordanengo V, Grosgeorge J, Turc-Carel C, Lefebvre JC (April 1999). “Cloning, mapping, and genomic organization of the LSLCL gene, encoding a new lymphocytic secreted mucin-like protein with a C-type lectin domain: A new model of exon shuffling”. Genomics. 57 (2): 316–7. doi:10.1006/geno.1999.5762. PMID 10198175.
  • Gehling UM, Ergün S, Schumacher U, Wagener C, Pantel K, Otte M, Schuch G, Schafhausen P, Mende T, Kilic N, Kluge K, Schäfer B, Hossfeld DK, Fiedler W (May 2000). “In vitro differentiation of endothelial cells from AC133-positive progenitor cells”. Blood. 95 (10): 3106–12. PMID 10807776.
  • Perrin C, Bayle J, Bannwarth S, Michiels JF, Heudier P, Lefebvre JC, Giordanengo V (December 2001). “Expression of LSLCL, a new C-type lectin, is closely restricted, in bone marrow, to immature neutrophils”. Comptes Rendus de l’Académie des Sciences, Série III. 324 (12): 1125–32. doi:10.1016/s0764-4469(01)01392-0. PMID 11803813.
  • Hiraoka A, Yano Ki K, Kagami N, Takeshige K, Mio H, Anazawa H, Sugimoto S (2002). “Stem cell growth factor: in situ hybridization analysis on the gene expression, molecular characterization and in vitro proliferative activity of a recombinant preparation on primitive hematopoietic progenitor cells”. The Hematology Journal. 2 (5): 307–15. doi:10.1038/sj.thj.6200118. PMID 11920266.
  • Ito C, Sato H, Ando K, Watanabe S, Yoshiba F, Kishi K, Furuya A, Shitara K, Sugimoto S, Kohno H, Hiraoka A, Hotta T (August 2003). “Serum stem cell growth factor for monitoring hematopoietic recovery following stem cell transplantation”. Bone Marrow Transplantation. 32 (4): 391–8. doi:10.1038/sj.bmt.1704152. PMID 12900775.
  • Lee E, Min HK, Oskeritzian CA, Kambe N, Schwartz LB, Wook Chang H (November 2003). “Recombinant human (rh) stem cell factor and rhIL-4 stimulate differentiation and proliferation of CD3+ cells from umbilical cord blood and CD3+ cells enhance FcepsilonR1 expression on fetal liver-derived mast cells in the presence of rhIL-4”. Cellular Immunology. 226 (1): 30–6. doi:10.1016/j.cellimm.2003.11.001. PMID 14746805.
  • Hollenbeck ST, Sakakibara K, Faries PL, Workhu B, Liu B, Kent KC (August 2004). “Stem cell factor and c-kit are expressed by and may affect vascular SMCs through an autocrine pathway”. The Journal of Surgical Research. 120 (2): 288–94. doi:10.1016/j.jss.2004.01.005. PMID 15234225.
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