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CLEC12A
Introduction
C-type lectin domain family 12 member A is a protein that in humans is encoded by the CLEC12A gene.[1]
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13.[1]
External links
External links
- Human CLEC12A genome location and CLEC12A gene details page in the UCSC Genome Browser.
Further reading
Further reading
- Drickamer K (1999). “C-type lectin-like domains”. Curr. Opin. Struct. Biol. 9 (5): 585–90. doi:10.1016/S0959-440X(99)00009-3. PMID 10508765.
- van Rhenen A, van Dongen GA, Kelder A, et al. (2007). “The novel AML stem cell associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells”. Blood. 110 (7): 2659–66. doi:10.1182/blood-2007-03-083048. PMID 17609428.
- Marshall AS, Willment JA, Pyz E, et al. (2006). “Human MICL (CLEC12A) is differentially glycosylated and is down-regulated following cellular activation”. Eur. J. Immunol. 36 (8): 2159–69. doi:10.1002/eji.200535628. PMID 16838277.
- Chen CH, Floyd H, Olson NE, et al. (2006). “Dendritic-cell-associated C-type lectin 2 (DCAL-2) alters dendritic-cell maturation and cytokine production”. Blood. 107 (4): 1459–67. doi:10.1182/blood-2005-08-3264. PMC 1895401. PMID 16239426.
- Bakker AB, van den Oudenrijn S, Bakker AQ, et al. (2005). “C-type lectin-like molecule-1: a novel myeloid cell surface marker associated with acute myeloid leukemia”. Cancer Res. 64 (22): 8443–50. doi:10.1158/0008-5472.CAN-04-1659. PMID 15548716.
- Han Y, Zhang M, Li N, et al. (2004). “KLRL1, a novel killer cell lectinlike receptor, inhibits natural killer cell cytotoxicity”. Blood. 104 (9): 2858–66. doi:10.1182/blood-2004-03-0878. PMID 15238421.
- Marshall AS, Willment JA, Lin HH, et al. (2004). “Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes”. J. Biol. Chem. 279 (15): 14792–802. doi:10.1074/jbc.M313127200. PMID 14739280.
- Ebner S, Sharon N, Ben-Tal N (2003). “Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily”. Proteins. 53 (1): 44–55. doi:10.1002/prot.10440. PMID 12945048.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.