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CLSTN1
Introduction
Calsyntenin-1 is a protein that in humans is encoded by the CLSTN1 gene.[1][2]
Clinical relevance
Clinical relevance
Mutations in this gene have been shown associated to pathogenic mechanisms of Alzheimer’s disease.[3]
Interactions
Interactions
CLSTN1 has been shown to interact with APBA2[4][5] and Amyloid precursor protein.[4][5]
References
References
- β Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). “Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro”. DNA Research. 5 (6): 355β64. doi:10.1093/dnares/5.6.355. PMIDΒ 10048485.
- β “Entrez Gene: CLSTN1 calsyntenin 1”.
- β Vagnoni A, Perkinton MS, Gray EH, Francis PT, Noble W, Miller CC (Jul 2012). “Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates AΞ² production”. Human Molecular Genetics. 21 (13): 2845β54. doi:10.1093/hmg/dds109. PMCΒ 3373235. PMIDΒ 22434822.
- β 4.0 4.1 Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, Suzuki T (Dec 2003). “Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism”. The Journal of Biological Chemistry. 278 (49): 49448β58. doi:10.1074/jbc.M306024200. PMIDΒ 12972431.
- β 5.0 5.1 Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T (Jun 2004). “Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation”. The Journal of Biological Chemistry. 279 (23): 24343β54. doi:10.1074/jbc.M401925200. PMIDΒ 15037614.
External links
External links
- Human CLSTN1 genome location and CLSTN1 gene details page in the UCSC Genome Browser.
- Human PIK3CD genome location and PIK3CD gene details page in the UCSC Genome Browser.
Further reading
Further reading
- Konecna A, Frischknecht R, Kinter J, Ludwig A, Steuble M, Meskenaite V, IndermΓΌhle M, Engel M, Cen C, Mateos JM, Streit P, Sonderegger P (Aug 2006). “Calsyntenin-1 docks vesicular cargo to kinesin-1” (PDF). Molecular Biology of the Cell. 17 (8): 3651β63. doi:10.1091/mbc.E06-02-0112. PMCΒ 1525238. PMIDΒ 16760430.
- Schmitt-Ulms G, Hansen K, Liu J, Cowdrey C, Yang J, DeArmond SJ, Cohen FE, Prusiner SB, Baldwin MA (Jun 2004). “Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues”. Nature Biotechnology. 22 (6): 724β31. doi:10.1038/nbt969. PMIDΒ 15146195.
- Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T (Jun 2004). “Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation”. The Journal of Biological Chemistry. 279 (23): 24343β54. doi:10.1074/jbc.M401925200. PMIDΒ 15037614.
- Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, Suzuki T (Dec 2003). “Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism”. The Journal of Biological Chemistry. 278 (49): 49448β58. doi:10.1074/jbc.M306024200. PMIDΒ 12972431.
- Nakayama M, Kikuno R, Ohara O (Nov 2002). “Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs”. Genome Research. 12 (11): 1773β84. doi:10.1101/gr.406902. PMCΒ 187542. PMIDΒ 12421765.
- Vogt L, Schrimpf SP, Meskenaite V, Frischknecht R, Kinter J, Leone DP, Ziegler U, Sonderegger P (Jan 2001). “Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain”. Molecular and Cellular Neurosciences. 17 (1): 151β66. doi:10.1006/mcne.2000.0937. PMIDΒ 11161476.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). “Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library”. Gene. 200 (1β2): 149β56. doi:10.1016/S0378-1119(97)00411-3. PMIDΒ 9373149.
- Maruyama K, Sugano S (Jan 1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1β2): 171β4. doi:10.1016/0378-1119(94)90802-8. PMIDΒ 8125298.