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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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CNTN2

Introduction

Contactin 2 (axonal), also known as CNTN2, is a human gene.[1]

The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention.[1]

References

References

  1. ↑ 1.0 1.1 “Entrez Gene: CNTN2 contactin 2 (axonal)”.
Further reading

Further reading

  • Walsh FS, Doherty P (1992). “Glycosylphosphatidylinositol anchored recognition molecules that function in axonal fasciculation, growth and guidance in the nervous system”. Cell Biol. Int. Rep. 15 (11): 1151–66. PMID 1838307.
  • Kuhn TB, Stoeckli ET, Condrau MA; et al. (1991). “Neurite outgrowth on immobilized axonin-1 is mediated by a heterophilic interaction with L1(G4)”. J. Cell Biol. 115 (4): 1113–26. PMID 1720120.
  • Dodd J, Morton SB, Karagogeos D; et al. (1990). “Spatial regulation of axonal glycoprotein expression on subsets of embryonic spinal neurons”. Neuron. 1 (2): 105–16. PMID 3272160.
  • Kenwrick S, Leversha M, Rooke L; et al. (1993). “Localization of the human TAX-1 gene to 1q32.1: a region implicated in microcephaly and Van der Woude syndrome”. Hum. Mol. Genet. 2 (9): 1461–2. PMID 8242070.
  • Tsiotra PC, Karagogeos D, Theodorakis K; et al. (1994). “Isolation of the cDNA and chromosomal localization of the gene (TAX1) encoding the human axonal glycoprotein TAG-1”. Genomics. 18 (3): 562–7. PMID 8307567.
  • Rader C, Stoeckli ET, Ziegler U; et al. (1993). “Cell-cell adhesion by homophilic interaction of the neuronal recognition molecule axonin-1”. Eur. J. Biochem. 215 (1): 133–41. PMID 8344273.
  • Hasler TH, Rader C, Stoeckli ET; et al. (1993). “cDNA cloning, structural features, and eucaryotic expression of human TAG-1/axonin-1”. Eur. J. Biochem. 211 (1–2): 329–39. PMID 8425542.
  • Kozlov SV, Giger RJ, Hasler T; et al. (1996). “The human TAX1 gene encoding the axon-associated cell adhesion molecule TAG-1/axonin-1: genomic structure and basic promoter”. Genomics. 30 (2): 141–8. doi:10.1006/geno.1995.9892. PMID 8586412.
  • Yoshihara Y, Kawasaki M, Tamada A; et al. (1996). “Overlapping and differential expression of BIG-2, BIG-1, TAG-1, and F3: four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily”. J. Neurobiol. 28 (1): 51–69. doi:10.1002/neu.480280106. PMID 8586965.
  • Milev P, Maurel P, Häring M; et al. (1996). “TAG-1/axonin-1 is a high-affinity ligand of neurocan, phosphacan/protein-tyrosine phosphatase-zeta/beta, and N-CAM”. J. Biol. Chem. 271 (26): 15716–23. PMID 8663515.
  • Pise-Masison CA, Dittmer J, Clemens KE, Brady JN (1997). “Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y”. Mol. Cell. Biol. 17 (3): 1236–43. PMID 9032250.
  • Williams H, Schachner M, Wang B, Kenwrick S (1998). “Radiation hybrid mapping of the genes for tenascin-R (TNR), phosducin (PDC), laminin C1 (LAMC1), and TAX in 1q25-q32”. Genomics. 46 (1): 165–6. doi:10.1006/geno.1997.4994. PMID 9403076.
  • Malhotra JD, Tsiotra P, Karagogeos D, Hortsch M (1999). “Cis-activation of L1-mediated ankyrin recruitment by TAG-1 homophilic cell adhesion”. J. Biol. Chem. 273 (50): 33354–9. PMID 9837910.
  • Freigang J, Proba K, Leder L; et al. (2000). “The crystal structure of the ligand binding module of axonin-1/TAG-1 suggests a zipper mechanism for neural cell adhesion”. Cell. 101 (4): 425–33. PMID 10830169.
  • Rickman DS, Tyagi R, Zhu XX; et al. (2001). “The gene for the axonal cell adhesion molecule TAX-1 is amplified and aberrantly expressed in malignant gliomas”. Cancer Res. 61 (5): 2162–8. PMID 11280781.
  • Pavlou O, Theodorakis K, Falk J; et al. (2002). “Analysis of interactions of the adhesion molecule TAG-1 and its domains with other immunoglobulin superfamily members”. Mol. Cell. Neurosci. 20 (3): 367–81. PMID 12139915.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Traka M, Goutebroze L, Denisenko N; et al. (2003). “Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers”. J. Cell Biol. 162 (6): 1161–72. doi:10.1083/jcb.200305078. PMID 12975355.
  • Nagaraja GM, Kandpal RP (2004). “Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins”. Biochem. Biophys. Res. Commun. 313 (3): 654–65. PMID 14697242.

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