Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
CNTRL
Introduction
Centriolin is a protein that in humans is encoded by the CNTRL gene. It was previously known as CEP110.[1][2]
This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centriolin.[2]
References
References
- ↑ Guasch G, Mack GJ, Popovici C, Dastugue N, Birnbaum D, Rattner JB, Pebusque MJ (Mar 2000). “FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33)”. Blood. 95 (5): 1788–96. PMID 10688839.
- ↑ 2.0 2.1 “Entrez Gene: CEP110 centrosomal protein 110kDa”.
External links
External links
- Human CNTRL genome location and CNTRL gene details page in the UCSC Genome Browser.
Further reading
Further reading
- Gromley A, Yeaman C, Rosa J, et al. (2005). “Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission”. Cell. 123 (1): 75–87. doi:10.1016/j.cell.2005.07.027. PMID 16213214.
- Guinn BA, Bland EA, Lodi U, et al. (2005). “Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia”. Biochem. Biophys. Res. Commun. 335 (4): 1293–304. doi:10.1016/j.bbrc.2005.08.024. PMID 16112646.
- Jurczyk A, Gromley A, Redick S, et al. (2004). “Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly”. J. Cell Biol. 166 (5): 637–43. doi:10.1083/jcb.200405023. PMC 2172416. PMID 15337773.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gromley A, Jurczyk A, Sillibourne J, et al. (2003). “A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase”. J. Cell Biol. 161 (3): 535–45. doi:10.1083/jcb.200301105. PMC 2172935. PMID 12732615.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ou YY, Mack GJ, Zhang M, Rattner JB (2002). “CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation”. J. Cell Sci. 115 (Pt 9): 1825–35. PMID 11956314.
- Popovici C, Mattéi MG, Rattner JB, et al. (2000). “Assignment of the centrosomal protein 110 gene (Cep110) to mouse chromosome bands 2B-C1 by in situ hybridization”. Cytogenet. Cell Genet. 89 (3–4): 216–7. doi:10.1159/000015616. PMID 10965126.
- Osaki E, Nishina Y, Inazawa J, et al. (1999). “Identification of a novel Sry-related gene and its germ cell-specific expression”. Nucleic Acids Res. 27 (12): 2503–10. doi:10.1093/nar/27.12.2503. PMC 148454. PMID 10359848.
- Schütze S, Machleidt T, Adam D, et al. (1999). “Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling”. J. Biol. Chem. 274 (15): 10203–12. doi:10.1074/jbc.274.15.10203. PMID 10187805.
- Bonaldo MF, Lennon G, Soares MB (1997). “Normalization and subtraction: two approaches to facilitate gene discovery”. Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.