Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
CYP3A7
Introduction
CYP3A7 is an enzyme belonging to the cytochrome P450 family. It is 503 amino acids in size and shares 87% of its sequence with CYP3A4. It carries out a similar role in fetuses that CYP3A4 serves in adults.[1] The gene location is 7q22.1.[2]
The CYP3A group of enzymes are the most abundantly expressed members of the cytochrome P450 family in liver. They are responsible for the metabolism of more than 50% of all clinical pharmaceuticals.[3]
Notable alleles
Notable alleles
The CYP3A7*1C allele is associated with poor outcomes in some cancer patients, possibly because of the effect of the enzyme on some chemotherapy agents.[4]
References
References
- ↑ Komori M, Nishio K, Ohi H, Kitada M, Kamataki T (February 1989). “Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450”. J. Biochem. 105 (2): 161–3. PMID 2722762.
- ↑ “Cytochrome P450, Subfamily IIIA, Polypeptide 7”. OMIM. Retrieved March 14, 2013.
- ↑ Paulussen A, Lavrijsen K, Bohets H, Hendrickx J, Verhasselt P, Luyten W, Konings F, Armstrong M (July 2000). “Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans”. Pharmacogenetics. 10 (5): 415–24. doi:10.1097/00008571-200007000-00005. PMID 10898111.
- ↑ CYP3A7*1C Allele Associated With Poor Outcomes in CLL, Breast, and Lung Cancer
External links
External links
- CYP3A7 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CYP3A7 genome location and CYP3A7 gene details page in the UCSC Genome Browser.