Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Calciphylaxis pathophysiology
Introduction
Overview
Overview
Pathophysiology
Pathophysiology
Calciphylaxis is characterised by
- systemic medial calcification of the arteries, i.e. calcification of tunica media. Unlike other forms of vascular calcifications (eg, intimal, medial, valvular), calciphylaxis is characterised also by
- small vessel mural calcification with or without endovascular fibrosis, extravascular calcification and vascular thrombosis, leading to tissue ischaemia (including skin ischaemia and, hence, skin necrosis).
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]