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Reliable, easy-to-read patient information on common medical conditions ā€” written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Calcitriol

Introduction

Further information: Calcitriol (injection) and ”’Calcitriol (injection)”’
Further information: Calcitriol (oral) and ”’Calcitriol (oral)”’
Further information: Calcitriol (topical) and ”’Calcitriol (topical)”’

Calcitriol is the active form of vitamin D, normally made in the kidney.[1][2][3] It is also known as 1,25-dihydroxycholecalciferol. It is a hormone which binds to and activates the vitamin D receptor in the nucleus of the cell, which then increases the expression of many genes.[4] Calcitriol increases blood calcium (Ca2+) mainly by increasing the uptake of calcium from the intestines.[5]

References

References

  1. ā†‘ Plum LA, DeLuca HF (December 2010). “Vitamin D, disease and therapeutic opportunities”. Nature Reviews. Drug Discovery. 9 (12): 941ā€“955. doi:10.1038/nrd3318. PMIDĀ 21119732.
  2. ā†‘ Encyclopedia of Endocrine Diseases. Academic Press. 2018. p.Ā 344. ISBNĀ 9780128122006.
  3. ā†‘ “Office of Dietary Supplements – Vitamin D”. ods.od.nih.gov. 9 October 2020. Retrieved 31 October 2020.
  4. ā†‘ Norman AW (August 2008). “From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health”. The American Journal of Clinical Nutrition. 88 (2): 491Sā€“499S. doi:10.1093/ajcn/88.2.491S. PMIDĀ 18689389.
  5. ā†‘ “Calcitriol Monograph for Professionals”. Drugs.com. American Society of Health-System Pharmacists. Retrieved 9 April 2019.
External links