Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Calicheamicin
Introduction
Calicheamicin is an antibiotic derived from organism Micromonospora echinospora. It was isolated originally from a rock collected in Waco, Texas by a hiking Scripps Institute chemist.
It is highly toxic but has found pharmacological use as a conjugate in antibody cancer therapeutics (e.g. Gemtuzumab).
References
- http://www.scripps.edu/newsandviews/e_20010226/nicolaou3.html
- J Antibiot (Tokyo). 1989 Jul;42(7):1070-87.