Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Cancer of unknown primary origin historical perspective
Introduction
Overview
Overview
Cancer of unknown primary origin was first discovered in the 1980s and was based solely on imaging studies.
Historical Perspective
Historical Perspective
Discovery
- Cancer of unknown primary origin was discovered in the 1980s.
- In the beginning, cancer of unknown primary was defined based on imaging results and only few empirical therapy options were available.[1]
Landmark Events in the Development of Treatment Strategies
- Between 1980 and 1990, the definition of cancer of unknown primary origin was based solely on imaging and treatment was limited to few empirical therapies.
- From 1990 to 2000, improvement in imaging techniques and immunohistochemical testing aided in the diagnosis of CUP. This time range also saw the rise of empirical therapy in treating CUP.
- In 2000, the emergence of tissue-of-origin molecular profiling, provided a more successful site-directed therapy especially when used with immunohistochemical testing
References
References
- ↑ Varadhachary GR, Raber MN (2014). “Cancer of unknown primary site”. N Engl J Med. 371 (8): 757–65. doi:10.1056/NEJMra1303917. PMID 25140961.
- ↑ Greco FA, Spigel DR, Yardley DA, Erlander MG, Ma XJ, Hainsworth JD (2010). “Molecular profiling in unknown primary cancer: accuracy of tissue of origin prediction”. Oncologist. 15 (5): 500–6. doi:10.1634/theoncologist.2009-0328. PMC 3227979. PMID 20427384.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: ; Roukoz A. Karam, M.D.[2]