Cancer of unknown primary origin physical examination

There are no remarkable findings in the physical examination of CUP patients; the presentation is variable and depends on many factors including the primary tumor’s origin and extent of organs involved.

• There are no remarkable findings in the physical examination of CUP patients; the presentation is variable and depends on many factors including the primary tumor’s origin and extent of organs involved.
• Usually patients with cancer of unknown origin present with involvement of multiple sites of metastases including bone, lung, liver, and lymph nodes.
• Physicians must conduct exhaustive physical examinations including head and neck, skin, genitourinary, breast, and rectal examinations.^[1]

• Patients with cancer of unknown primary origin usually appear cachexic.^[1]

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