Patients with capillary leak syndrome present with generalized edema, weight gain, fatigue, and body aches. Physical examination is remarkable from hypotension, rash, pruritus, flushing, jaw claudication. Lung examination may reveal wheezing and prolonged expiratory phase. Cardiac examination may reveal tachycardia, weak peripheral pulses, muffled heart sounds on auscultation due to underlying pericardial effusion, pulsus paradoxus, and pericardial friction rub. The patient may also present with abdominal distention, tenderness, and fluid thrill.

Patient with capillary leak syndrome usually presents with generalized edema fatigued, and body aches^[1]. Physical examination is usually remarkable for hypotension, pleural and pericardial effusion.^[1]

• Partial or generalized edema may be seen.
• Weight gain

• Low blood pressure (hypotension)

• Generalized edema or anasarca
• Rash
• Pruritus
• Flushing

• Jaw claudication

• Unremarkable

• Wheezing may be present
• Prolonged expiratory phase

• Tachycardia
• Weak peripheral pulses
• Muffled heart sounds on auscultation due to underlying pericardial effusion
• Pulsus Paradoxus
• Pericardial friction rub

• Abdominal tenderness
• Abdominal distention
• Fluid thrill

• Generalized edema

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