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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Carboxypeptidase B

Introduction

Carboxypeptidase B (EC 3.4.17.2, protaminase, pancreatic carboxypeptidase B, tissue carboxypeptidase B, peptidyl-L-lysine [L-arginine]hydrolase) is a carboxypeptidase that preferentially acts upon basic amino acids, such as arginine and lysine.[1][2][3][4] This serum enzyme is also responsible for rapidly metabolizing the C5a protein into C5a des-Arg, with one less amino acid.

References

References

  1. ↑ Folk JE (1970). “Carboxypeptidase B (porcine pancreas)”. Methods Enzymol. 19: 504–508. doi:10.1016/0076-6879(70)19036-7.
  2. ↑ Brodrick JW, Geokas MC, Largman C (December 1976). “Human carboxypeptidase B. II. Purification of the enzyme from pancreatic tissue and comparison with the enzymes present in pancreatic secretion”. Biochimica et Biophysica Acta. 452 (2): 468–81. doi:10.1016/0005-2744(76)90197-2. PMID 1009123.
  3. ↑ Butterworth J, Duncan JJ (September 1979). “Carboxypeptidase B activity of cultured skin fibroblasts and relationship to cystic fibrosis”. Clinica Chimica Acta; International Journal of Clinical Chemistry. 97 (1): 39–43. doi:10.1016/0009-8981(79)90023-8. PMID 40714.
  4. ↑ Wallace EF, Evans CJ, Jurik SM, Mefford IN, Barchas JD (1982). “Carboxypeptidase B activity from adrenal medulla–is it involved in the processing of proenkephalin?”. Life Sciences. 31 (16–17): 1793–6. doi:10.1016/0024-3205(82)90212-0. PMID 6130442.
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