Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Cardiac allograft vasculopathy medical therapy
Introduction
Overview
Overview
Once CAV has developed, pharmacologic options to halt progression are limited. Moreover, outcomes resulting from available treatment have been disappointing. Retransplantation is the only definitive treatment of established CAV. Ideal regimen should not affect the lipid profile, blood pressures and renal function, and should have a positive impact on hemodynamics.
Medical Therapy
Medical Therapy
Treatment option for established CAV include:
| Pharmacological Management | Non-pharmacological Interventions |
Pharmacologic Management
High Dose Immunosuppressive Therapy
- Lamich and colleagues [1] studied the effects of augmented immunosuppressive therapy on progression of established CAV in a prospective trial of 76 cardiac allograft recipients. They concluded that the likelihood of CAV regression is higher when treatment was instituted within one year of transplant (92%) compared to after one year (40%) (P=0.033).
- However, this is not routinely practiced as the risks of high dose immunosuppressive therapy outweighs the benefits.
References
References
- ↑ Lamich R, Ballester M, Martà V, Brossa V, Aymat R, Carrió I; et al. (1998). “Efficacy of augmented immunosuppressive therapy for early vasculopathy in heart transplantation”. J Am Coll Cardiol. 32 (2): 413–9. PMID 9708469.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aarti Narayan, M.B.B.S [2]; Raviteja Guddeti, M.B.B.S. [3]