Cardiac tumors causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dheeraj Makkar, M.D.[2]

Overview

Numerous genetic disorders are associated with cardiac tumors however, till now no direct causes have been identified.

Causes

Many genetic conditions are strongly associated with a large number of heart tumors. Some of them are as follows:^[1]

Cardiac tumors genetic causes
Tumor	Syndrome	Gene Associated with syndrome
Rhabdomyoma	Tuberous Sclerosis	TSC1 or hamartin TSC2 or tuberin
Fibroma	Gorlin Syndrome	PATCHED gene
Myxoma	Carney Complex	Inactivating mutation of PRKARA1A Activating pathogenic variant of PRKACA gene
Paraganglioma	Carney triad	No known gene associations
Paraganglioma	Hereditary Paraganglioma	Mutation of succinate dehydrogenase subunit SDHAF2 gene, and possibly MAX gene but these mutations are rare
Paraganglioma	Von Hippel Lindau	VHL gene
Paraganglioma	Neurofibromatosis type 1	NF1 gene

References

Overview