Carmofur

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Carmofur (INN) or HCFU (1-hexylcarbamoyl-5-fluorouracil) is a pyrimidine analogue used as an antineoplastic agent. It is a derivative of fluorouracil.

Uses

Breast Cancer

Colorectal Cancer

Carmofur, in its oral form, has also been used as adjuvant chemotherapy for curatively resected colorectal cancer patients. Trials and meta-analyses have confirmed that the drug is effective on patients with this cancer type, extending their survival.^[1]

Adverse effects

As fluorouracil, carmofur has been known to induce leukoencephalopathy.^[2]^[3]^[4]

References

↑ Sakamoto, J; Hamada, C; Rahman, M; Kodaira, S; Ito, K; Nakazato, H; Ohashi, Y; Yasutomi, M (2005). “An Individual Patient Data Meta-analysis of Adjuvant Therapy with Carmofur in Patients with Curatively Resected Colon Cancer”. Japanese Journal of Clinical Oncology. 35 (9): 536–544. doi:10.1093/jjco/hyi147. PMID 16155120.
↑ Yamada T, Okamura S, Okazaki T; et al. (June 1989). “Leukoencephalopathy following treatment with carmofur: a case report and review of the Japanese literature”. Asia Oceania J Obstet Gynaecol. 15 (2): 161–8. PMID 2667512.
↑ Mizutani T (February 2008). “[Leukoencephalopathy caused by antineoplastic drugs]”. Brain Nerve (in Japanese). 60 (2): 137–41. PMID 18306661.
↑ Baehring JM, Fulbright RK (May 2008). “Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients”. J Neurol Neurosurg Psychiatr. 79 (5): 535–9. doi:10.1136/jnnp.2007.123737. PMID 17682013.

[1] Sakamoto, J; Hamada, C; Rahman, M; Kodaira, S; Ito, K; Nakazato, H; Ohashi, Y; Yasutomi, M (2005). “An Individual Patient Data Meta-analysis of Adjuvant Therapy with Carmofur in Patients with Curatively Resected Colon Cancer”. Japanese Journal of Clinical Oncology. 35 (9): 536–544. doi:10.1093/jjco/hyi147. PMID 16155120.

[2] Yamada T, Okamura S, Okazaki T; et al. (June 1989). “Leukoencephalopathy following treatment with carmofur: a case report and review of the Japanese literature”. Asia Oceania J Obstet Gynaecol. 15 (2): 161–8. PMID 2667512.

[3] Mizutani T (February 2008). “[Leukoencephalopathy caused by antineoplastic drugs]”. Brain Nerve (in Japanese). 60 (2): 137–41. PMID 18306661.

[4] Baehring JM, Fulbright RK (May 2008). “Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients”. J Neurol Neurosurg Psychiatr. 79 (5): 535–9. doi:10.1136/jnnp.2007.123737. PMID 17682013.

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