Routine screening for CTS in the general population is not indicated. Instead, a targeted approach—using symptom questionnaires, physical exam maneuvers, and selective imaging or nerve conduction studies—is recommended for high-risk occupations and patients with systemic predispositions.

Carpal tunnel syndrome is primarily a clinical diagnosis, and there are no population-based screening programs recommended for asymptomatic individuals. Instead, screening is generally targeted toward high-risk groups and focused on early detection of symptomatic disease to prevent progression.

• At-Risk Populations:

Workers exposed to repetitive wrist motions, vibrating tools, or prolonged computer use.

Patients with systemic risk factors: diabetes, hypothyroidism, obesity, rheumatoid arthritis, pregnancy, or amyloidosis.

• Screening Tools:

Symptom questionnaires and diagrams: The self-administered hand diagram is highly specific (~76%) for CTS.

• Provocative maneuvers: Phalen’s test, Tinel’s sign, and the carpal tunnel compression test (Durkan’s) are used in outpatient or occupational health settings for early identification.

• Sensory testing: Semmes–Weinstein monofilament testing and two-point discrimination may detect early sensory deficits.

• Electrodiagnostic studies: Not suitable for general screening, but used to confirm diagnosis in equivocal or high-risk cases.

• Ultrasound: Increasingly used for screening in selected groups, as it can demonstrate median nerve enlargement and structural causes noninvasively.