Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Castleman's disease natural history, complications and prognosis
Introduction
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Overview
Overview
Natural History
Natural History
Complications
Complications
- Life threatening infections
- Multi organ failure
- Kaposi sarcoma
- Lymphoma
- Death
Prognosis
Prognosis
- Prior to 1996 MCD carried a poor prognosis of about 2 years, due to autoimmune hemolytic anemia and non-Hodgkin’s lymphoma which may arise as a result of proliferation of infected cells. The timing of diagnosis, with particular attention to the difficulty of determining the cause of B symptoms without a CT scan and lymph node biopsy, may impact significantly on the prognosis and risk of death. Left untreated, MCD usually gets worse and becomes increasingly difficult and unresponsive to current treatment regimens.
- HIV patients with multicentric disease have a grave prognosis. They have a less favorable clinical course and tend to develop Kaposi sarcoma and even plasmablastic non-Hodgkin lymphoma.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]