Castleman's disease other diagnostic studies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]

Overview

Biopsy

Lymph node biopsy is used as a differentiating tool in the diagnosis of Castleman’s disease. It is used to differentiate Castleman’s from lymphoma.
Variants of Castleman’s disease can also be differentiated using biopsy.


Micrograph of Castleman’s disease, hyaline vascular variant, exhibiting the characteristically expanded mantle zone and a radially penetrating sclerotic blood vessel (“lollipop” sign). H&E stain.	Intermediate magnification micrograph of Castleman disease showing the characteristic expansion of the mantle zone, known as “onion skinning”. H&E stain.

References

Overview