If left untreated, approximately 30% of patients experience at least one cardiac arrest and up to 80% one or more syncopal spells. Common complications of catecholaminergic polymorphic ventricular tachycardia include ventricular fibrillation, sudden cardiac arrest, and sudden cardiac death. Prognosis is generally poor, and the 10-year mortality of patients with catecholaminergic polymorphic ventricular tachycardia is approximately 40%.

• The symptoms of CPVT usually develop during childhood and adolescence, in the first and second decades of life, and start with symptoms such as episodes of syncope.
• More than 30% of affected individuals will experience symptoms before the age of 10 years and the majority (60% to 80%) of the patients will have one or more symptomatic arrhythmia episodes before age 40.^{[1] [2] [3] [4]}
• However, molecular analysis showed that there is a small group of patients who remain asymptomatic, even after exercise tests suggesting them to be having normal phenotype CPVT (mutation carriers). Some of these phenotypically normal patients with CVPT do experience syncope and sudden death.^[5]
• If left untreated, CPVT is highly lethal, as approximately 30% of patients experience at least one cardiac arrest and up to 80% one or more syncopal spells.^[1][2]
• The polymorphic ventricular tachycardia may self-terminate or it may degenerate into ventricular fibrillation, causing sudden cardiac death.

• Common complications of catecholaminergic polymorphic ventricular tachycardia include:
  • Ventricular fibrillation
  • Sudden cardiac arrest
  • Sudden cardiac death

• Prognosis is generally poor, and the 10-year mortality of patients with CPVT is approximately 40%.^[3]
• Studies show that there is a correlation between the age of the first syncope and the severity of the disease, with a worse prognosis in the case of early occurrence.^[1]
• If left untreated, patients with CPVT have a mortality rate of 30% before age 40.^[2][5]