Cavernous sinus thrombosis physical examination

Physical examination of patients with cavernous sinus thrombosis is usually remarkable for high grade fever, Tachycardia with regular pulse, Tachypnea, low blood pressure with normal pulse pressure, Pallor of skin, Altered mental status, Periorbital edema (initially unilateral but typically bilateral), unilateral or bilateral exophthalmos, abnormal extra-ocular movements from third, fourth and sixth cranial neuropathy, non-reactive pupils to neither light nor accommodation (from paralysis of the iris and ciliary body), lid erythema, horner syndrome (ptosis, miosis, and anhidrosis), Chemosis, Ptosis, Proptosis (due to impaired venous drainage of orbit, painful eye movement, Papilledema, retinal hemorrhages, decreased visual acuity, Photophobia, pulsating conjunctiva, facial tenderness, impaired corneal reflex, blindness, stiff neck, Photophobia, Hyperreflexia, generalised weakness, downgoing plantar reflex, Ptosis and Hemiparesis.

• Patients with cavernous sinus thrombosis usually appear very ill and toxic.^[1][2][3]

• High-grade fever^[2][3]
• Tachycardia with regular pulse^[2][3]
• Tachypnea^[4]
• Low blood pressure with normal pulse pressure

• Pallor may be present^[2]

• Periorbital edema (initially unilateral but typically bilateral)^[5][2][3][6]
• Unilateral or bilateral exophthalmos^[7][2][3][5]
• Extra-ocular movements may be abnormal from third, fourth and sixth cranial neuropathy^[2][3][5]
  • Sixth cranial nerve neuropathy is the most common neuropathy (resulting in partial ophthalmoplegia with limited eye abduction).^[2][3][5]
• Pupils non-reactive to neither light nor accommodation (from paralysis of the iris and ciliary body)^[5]
• Lid erythema^[5]
• Horner syndrome (ptosis, miosis, and anhidrosis)^[5][8]
• Chemosis^[2][5]
• Ptosis^[5][8]
• Proptosis (due to impaired venous drainage of orbit)^[2][5]
• Painful eye movement^[2][5]
• Papilledema^[5]
• Retinal hemorrhages^[5]
• Decreased visual acuity^[5]
• Photophobia^[1]
• Pulsating conjunctiva^[2]
• Facial tenderness^[2][3]
• Impaired corneal reflex^[5][5]
• Blindness^[9][10]

• Stiff neck may be present.^[2]

• Pulmonary examination of patients with cavernous sinus thrombosis is usually normal.

• Cardiovascular examination of patients with cavernous sinus thrombosis is usually normal.

• Abdominal examination of patients with cavernous sinus thrombosis is usually normal.

• Back examination of patients with cavernous sinus thrombosis is usually normal.

• Genitourinary examination of patients with cavernous sinus thrombosis is usually normal.

• Altered mental status^[2][3]
• Extra-ocular movements may be abnormal from third, fourth and sixth cranial neuropathy^[2][3][5]
  • Sixth cranial nerve neuropathy is the most common neuropathy (resulting in partial ophthalmoplegia with limited eye abduction).^[2][5]
• Photophobia^[11]
• Horner syndrome (ptosis, miosis, and anhidrosis)^[2][5][8]
• Hyperreflexia^[12]
• Generalised weakness^[1]
• Decreased visual acuity^[10]
• Downgoing plantar reflex^[13]
• Ptosis^[5][8]
• Hemiparesis^[13]
• Blindness^[9][10]

• Extremities examination of patients with cavernous sinus thrombosis is usually normal.

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