Developer site: The content shown here is test data.

MyEClinic
MyEClinic
Health Dictionary AI Health Chat Find an Online Doctor
A serene Zen garden with raked sand and smooth stones, symbolising clarity and calm

Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

Back to skin conditions

Celiac disease causes

Introduction

Overview

Overview

The common causes of celiac disease are autoantibodies to gluten and certain genetic factors.

Causes

Causes

The common causes of celiac disease are autoantibodies to gluten and certain genetic factors.[1][2]

Common Causes

Celiac disease is usually caused by:

  • Autoantibodies against gluten which is found in:

Genetic Causes

  • Celiac disease is linked to the HLA genes usually HLA DQ2 and HLA DQ8.
    • CELIAC1 (6p21)
  • Non-HLA genes are also thought to be related to celiac disease:
    • CELIAC2 (5q31-33)
    • CELIAC3 (2q33)
    • CELIAC4 (19p13·1)
References

References

  1. ↑ Di Sabatino A, Corazza GR (2009). “Coeliac disease”. Lancet. 373 (9673): 1480–93. doi:10.1016/S0140-6736(09)60254-3. PMID 19394538.
  2. ↑ Heap GA, van Heel DA (2009). “Genetics and pathogenesis of coeliac disease”. Semin. Immunol. 21 (6): 346–54. doi:10.1016/j.smim.2009.04.001. PMID 19443237.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]