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Celiac disease causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]

Overview

Overview

The common causes of celiac disease are autoantibodies to gluten and certain genetic factors.

Causes

Causes

The common causes of celiac disease are autoantibodies to gluten and certain genetic factors.[1][2]

Common Causes

Celiac disease is usually caused by:

  • Autoantibodies against gluten which is found in:

Genetic Causes

  • Celiac disease is linked to the HLA genes usually HLA DQ2 and HLA DQ8.
    • CELIAC1 (6p21)
  • Non-HLA genes are also thought to be related to celiac disease:
    • CELIAC2 (5q31-33)
    • CELIAC3 (2q33)
    • CELIAC4 (19p13·1)
References

References

  1. ↑ Di Sabatino A, Corazza GR (2009). “Coeliac disease”. Lancet. 373 (9673): 1480–93. doi:10.1016/S0140-6736(09)60254-3. PMID 19394538.
  2. ↑ Heap GA, van Heel DA (2009). “Genetics and pathogenesis of coeliac disease”. Semin. Immunol. 21 (6): 346–54. doi:10.1016/j.smim.2009.04.001. PMID 19443237.

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