Chlorphenesin
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Overview
Chlorphenesin (Maolate, Musil) is a centrally acting muscle relaxant used to treat muscle pain and spasms.[1][2] Chlorphenesin is no longer used for this purpose in most developed nations due to the availability of much safer spasmolytics such as benzodiazepines.
Other central effects include sedation, anxiolysis, and dizziness. It also has antifungal and some antibacterial properties and is thus classified as an antifungal for topical use by the WHO.[3]
Safety
Safety
The major adverse effect from this preservative on skin is allergic contact sensitivity.[4][5] Systemic intoxication from transdermal use has not been observed, although the FDA discourages its use as an ingredient in nipple cream for nursing mothers.[6]
References
References
- ↑ Okuyama, S; Aihara, H (1987). “Antinociceptive effect of chlorphenesin carbamate in adjuvant arthritic rats”. Research communications in chemical pathology and pharmacology. 55 (2): 147–60. PMID 3823606.
- ↑ Kurachi, M; Aihara, H (1984). “Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats”. Japanese journal of pharmacology. 36 (1): 7–13. doi:10.1254/jjp.36.7. PMID 6503049.
- ↑ ATC code D01AE07
- ↑ Brown R (1981). “Chlorphenesin sensitivity”. Contact Dermatitis. 7 (3): 162. doi:10.1111/j.1600-0536.1981.tb04601.x. PMID 6456118.
- ↑ Burns DA (1986). “Allergic contact sensitivity to chlorphenesin”. Contact Dermatitis. 14 (33): 246. doi:10.1111/j.1600-0536.1986.tb01234.x. PMID 2941223.
- ↑ http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2008/ucm116900.htm. Missing or empty
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