Cholesterol emboli was first described by a Danish pathophysiologist called Peter Ludvig Panum in 1862. The first case series of Arterial Occlusions due to Emboli were reported from 267 autopsies in the New York Hospital by Curtis M. Flory in 1945. The cholesterol crystals were first identified by polarized light in 1956. atheromatous embolization following vascular surgery was first diagnosed by Thurlbeck and Castleman in 1957. The cholesterol emboli in the retinal arterioles was first described by an ophthalmologist called Dr Robert Hollenhorst in 1961, which is known as Hollenhorst plaques. In 1961, first cases of blue toe syndrome, described as painful toes, following treatment with oral anticoagulation were reported by Feder and Auerbach. But the term of blue toe syndrome was first used in 1976. The association between aortic plaque on TEE and development of emboli was reported in 1990.

• Cholesterol emboli was first described by a Danish pathophysiologist called Peter Ludvig Panum in 1862. ^{[1] [2]}
• In 1945, the first case series of Arterial Occlusions due to Emboli were reported from 267 autopsies in the New York Hospital by Curtis M. Flory. ^{[3] [2]}
• The cholesterol crystals were first identified by polarized light in 1956. ^[2]
• atheromatous embolization following vascular surgery was first diagnosed by Thurlbeck and Castleman in 1957. ^[2]
• The cholesterol emboli in the retinal arterioles was first described by an ophthalmologist called Dr Robert Hollenhorst in 1961, which is known as Hollenhorst plaques. ^[4]
• In 1961, first cases of blue toe syndrome described as painful toes following treatment with oral anticoagulation were reported by Feder and Auerbach. ^[5]But the term of blue toe syndrome was first used in 1976. ^[6]
• In 1990, the association between aortic plaque on TEE and development of emboli was first reported. ^[2]

• Embolism

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