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Cholesterol emboli syndrome physical examination

Introduction

Overview

Overview

Physical Examination

Physical Examination

  • Chest pain due to myocardial ischemia
  • Paradoxical embolus: presence of patent foramen ovale or atrial septal defect
  • Other rare manifestations include retinal lesions, splenic infarcts, prostatitis, orchitis, hemorrhagic cystitis
  • Fever

Abdomen

  • Abdominal pain
    • Occult blood positive stool due to ischemia of the stomach, small intestine and colon
    • Less common manifestations include ischemic pancreatitis, focal liver cell necrosis and acalculous necrotizing cholecystitis.
  • Renal failure
    • Acute or step-wise worsening function
    • Patients may demonstrate focal segmental glomerulosclerosis may be seen, presenting with progressive renal insufficiency, sometimes with significant proteinuria.

Neurologic

  • Neurologic abnormalities
    • Mononeuritis multiplex
    • CNS involvement

Skin

  • Cutaneous involvement – cutaneous involvement increases the likelihood of accurate diagnosis.
    • Blue toes / nail bed infarctions
    • Livedo reticularis – present in up to 50%
    • Cyanosis, purpura, tender nodules, ulcerations, gangrene
References

References


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]