Cholesterolosis of gallbladder

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Cholesterolosis of gallbladder is characterized by mucosal villous hyperplasia with excessive accumulation of cholesterol esters within epithelial macrophages. Choesterolosis may be localized in the form of individual polyps or it may be diffused when there are groups of polyps . Diffused cholesterolosis of gallbladder is also referred to as strawberry gallbladder. The condition is usually clinically silent, but is rarely associated with biliary symptoms or idiopathic pancreatitis and cannot be reliably detected by ultrasonography.

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• Gallbladder cholecystoses are conditions characterized by the accumulation of cholesterol and other fats in the gallbladder. The two main forms are adenomyomatosis and cholesterolosis.
• Cholesterolosis of gallbladder develops from deposition of triglycerides and cholesterol esters within the lamina propria of gallbladder wall causing mucosal hyperplasia.
• Deposition of cholesterol esters can be diffused or localized.
• Gross appearance of the mucosa of gallbladder wall due to diffuse cholesterolosis is known as “strawberry gallbladder”.
• Cholesterolosis should be differentiated from adenomyomatosis which involves hyperplasia of both mucosa and muscularis propria.^[1]

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

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Risk factors of cholesterolosis of gallbladder include:

• alcohol consumption
• smoking
• elevated serum cholesterol levels
• elevated BMI

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