Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Chondrosarcoma classification
Introduction
Overview
Overview
Chondrosarcoma may be classified based on histological findings and location.
Classification
Classification
- Chondrosarcoma be classified based on histological findings and location.
Histological Classification
- Chondrosarcoma may be classified based on histological findings into following groups:[1][2]
Primary Chondrosarcoma
- Chondrosarcoma that arises denovo and comprises of following subtypes:
- Conventional chondrosarcoma – Low-grade, high-grade, and dedifferentiated chondrosarcoma (90% of all chondrosarcomas)
- Clear cell chondrosarcoma (1% of all chondrosarcomas)
- Mesenchymal chondrosarcoma (2% of all chondrosarcomas)
Secondary Chondrosarcoma
- Chondrosarcoma that arises from benign cartilage lesions includes (7% of all chondrosarcomas):
- Osteochondroma (<1% risk of malignant transfomation)
- Multiple hereditary exostosis (1-10% risk of malignant transformation)
- Enchondromas (1% risk of malignant transformation)
- Ollier’s disease (25-40% risk of malignant transformation)
- Maffucci’s disease(100% risk of malignant transformation)
Based on Location
- Chondrosarcoma may be classified based on location into following groups:[3][4]
- Centrally located within the medullary cavity. (central chondrosarcoma) (70% of all chondrosarcomas)
- Peripherally located on the surface of bone as a result of malignant transformation within the cartilaginous cap. (Peripheral chondrosarcoma) (15% of all chondrosarcomas)
References
References
- ↑ Raymond E, L’Her P, Jeanbourquin D, Schill H, Jancovici R, Daly JP; et al. (1993). “[Chondrosarcoma of the thoracic wall. Review of the literature apropos of 4 cases]”. Rev Pneumol Clin. 49 (1): 19–25. PMID 8378694.
- ↑ Lex JR, Evans S, Stevenson JD, Parry M, Jeys LM, Grimer RJ (2018). “Dedifferentiated chondrosarcoma of the pelvis: clinical outcomes and current treatment”. Clin Sarcoma Res. 8: 23. doi:10.1186/s13569-018-0110-1. PMC 6293503. PMID 30559960.
- ↑ Giuffrida AY, Burgueno JE, Koniaris LG, Gutierrez JC, Duncan R, Scully SP (2009). “Chondrosarcoma in the United States (1973 to 2003): an analysis of 2890 cases from the SEER database”. J Bone Joint Surg Am. 91 (5): 1063–72. doi:10.2106/JBJS.H.00416. PMID 19411454.
- ↑ Skeletal Lesions Interobserver Correlation among Expert Diagnosticians (SLICED) Study Group (2007). “Reliability of histopathologic and radiologic grading of cartilaginous neoplasms in long bones”. J Bone Joint Surg Am. 89 (10): 2113–23. doi:10.2106/JBJS.F.01530. PMID 17908885.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rohan A. Bhimani, M.B.B.S., D.N.B., M.Ch.[2]