Chromoblastomycosis medical therapy

Chromoblastomycosis is very difficult to cure. There are two primary treatments of choice. Itraconazole, an antifungal azole, is given orally, with or without flucytosine (5-FC). Alternatively, cryosurgery with liquid nitrogen has also been shown to be effective. Other treatment options are the antifungal drug terbinafine, an experimental drug posaconazole, and heat therapy. Antibiotics may be used to treat bacterial superinfections.

• Chromoblastomycosis^[1]

• 1. If lesions small and few

• surgical excision or cryosurgery with liquid nitrogen.

• 2. If lesions chronic, extensive, burrowing

• Preferred regimen: Itraconazole 200-400 mg PO q24h OR 400 mg pulse therapy once daily for 1 week monthly for 6-12 months