Chronic liver disease
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2]
Overview
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Chronic liver disease is a liver disease of slow process and persisting over a long period of time, resulting in a progressive destruction of the liver.
Treatment
Medical Therapy
The treatment of chronic liver disease depends on the cause. While some conditions may be treated with medications, others may require surgery or a transplant. Transplant is required when the liver fails and there is no other alternative [1]. Because many chronic liver disorders have no cure, many people have been turning to alternative health care. Herbal supplements are widely used by many people with chronic liver disease. None of these herbs have ever been tested in randomized clinical trials and no one knows whether they work. Some common herbs known to be potentially harmful in liver disease include black cohosh, ma huang, chaparral, comfrey, germander, greater celandine, kava, mistletoe, pennyroyal, skull cap and valerian.
References
- ↑ Liver Disease Gastro.com – 27/01/2007/
Pathophysiology
Causes
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Causes
Life Threatening Causes
Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
Common Causes
- Alcoholic liver disease
- Autoimmune hepatitis
- Cirrhosis
- Gaucher disease
- Hemochromatosis
- Hepatitis B
- Hepatitis C
- Hepatoma
- Portal hypertension
- Primary biliary cirrhosis
- Primary sclerosing cholangitis
- Sarcoidosis
- Wilson’s disease
- Zellweger syndrome
Causes by Organ System
| Cardiovascular | Right heart failure |
| Chemical / poisoning | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | Methotrexate, Nitrofurantoin |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | Autoimmune hepatitis, Cirrhosis, Hepatitis B , Hepatitis C, Hepatoma, Non-alcoholic fatty liver disease, Portal hypertension, Primary biliary cirrhosis , Primary sclerosing cholangitis, Sarcoidosis, Wilson’s disease |
| Genetic | Gaucher disease, Hemochromatosis, Sarcoidosis, Wilson’s disease, Zellweger syndrome |
| Hematologic | No underlying causes |
| Iatrogenic | No underlying causes |
| Infectious Disease | Cytomegalovirus (CMV), Epstein Barr virus (EBV), Hepatitis B , Hepatitis C |
| Musculoskeletal / Ortho | No underlying causes |
| Neurologic | Wilson’s disease |
| Nutritional / Metabolic | Gaucher disease, Hemochromatosis, Zellweger syndrome |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | Hepatoma |
| Opthalmologic | Wilson’s disease |
| Overdose / Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | Sarcoidosis |
| Renal / Electrolyte | No underlying causes |
| Rheum / Immune / Allergy | Autoimmune hepatitis, Primary biliary cirrhosis , Primary sclerosing cholangitis, Sarcoidosis |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Dental | No underlying causes |
| Miscellaneous | Alcoholic liver disease |
Causes in Alphabetical Order
- Alcoholic liver disease
- Autoimmune hepatitis
- Cirrhosis
- Cytomegalovirus (CMV)
- Epstein Barr virus (EBV)
- Gaucher disease
- Hemochromatosis
- Hepatitis B
- Hepatitis C
- Hepatoma
- Metabolic
- Methotrexate
- Nitrofurantoin
- Non-alcoholic fatty liver disease
- Portal hypertension
- Primary biliary cirrhosis
- Primary sclerosing cholangitis
- Right heart failure
- Sarcoidosis
- Wilson’s disease
- Zellweger syndrome
References
Differentiating Chronic liver disease from other Diseases
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Differentiating Chronic Liver Disease from other Diseases
References
Epidemiology and Demographics
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Epidemiology and Demographics
References
Risk Factors
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Risk Factors
- Health care professionals who are exposed to body fluids and infected blood
- Individuals who get multiple tattoos and body piercing
- Certain prescription medications
- Excessive alcohol use
- Having high levels of fat in the blood
- Sharing infected needle and syringes
- Obesity
- Having unprotected sex and multiple sex partners
- Working with toxic chemicals without wearing safety clothes
References
Natural History, Complications and Prognosis
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Natural History
Complications
- Portal hypertension
- Hypoalbuminaemia
- Coagulopathy
- Hepatopulmonary syndrome
- Hepatorenal syndrome
- Encephalopathy
- Hepatocellular carcinoma (also called hepatoma)
Prognosis
Prognosis is assessed by
References
Diagnosis
Diagnosis
History and Symptoms | Physical Examination | Laboratory Findings | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies
Treatment
Treatment
Medical Therapy | Surgery | Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies
Related Chapters
Related Chapters
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