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Chronic liver disease

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2]

Overview

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Chronic liver disease is a liver disease of slow process and persisting over a long period of time, resulting in a progressive destruction of the liver.

Treatment

Medical Therapy

The treatment of chronic liver disease depends on the cause. While some conditions may be treated with medications, others may require surgery or a transplant. Transplant is required when the liver fails and there is no other alternative [1]. Because many chronic liver disorders have no cure, many people have been turning to alternative health care. Herbal supplements are widely used by many people with chronic liver disease. None of these herbs have ever been tested in randomized clinical trials and no one knows whether they work. Some common herbs known to be potentially harmful in liver disease include black cohosh, ma huang, chaparral, comfrey, germander, greater celandine, kava, mistletoe, pennyroyal, skull cap and valerian.

References

  1. Liver Disease Gastro.com – 27/01/2007/

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Pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Pathophysiology

References

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Causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

Common Causes

Causes by Organ System

Cardiovascular Right heart failure
Chemical / poisoning No underlying causes
Dermatologic No underlying causes
Drug Side Effect Methotrexate, Nitrofurantoin
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic Autoimmune hepatitis, Cirrhosis, Hepatitis B , Hepatitis C, Hepatoma, Non-alcoholic fatty liver disease, Portal hypertension, Primary biliary cirrhosis , Primary sclerosing cholangitis, Sarcoidosis, Wilson’s disease
Genetic Gaucher disease, Hemochromatosis, Sarcoidosis, Wilson’s disease, Zellweger syndrome
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease Cytomegalovirus (CMV), Epstein Barr virus (EBV), Hepatitis B , Hepatitis C
Musculoskeletal / Ortho No underlying causes
Neurologic Wilson’s disease
Nutritional / Metabolic Gaucher disease, Hemochromatosis, Zellweger syndrome
Obstetric/Gynecologic No underlying causes
Oncologic Hepatoma
Opthalmologic Wilson’s disease
Overdose / Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary Sarcoidosis
Renal / Electrolyte No underlying causes
Rheum / Immune / Allergy Autoimmune hepatitis, Primary biliary cirrhosis , Primary sclerosing cholangitis, Sarcoidosis
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Dental No underlying causes
Miscellaneous Alcoholic liver disease

Causes in Alphabetical Order

References

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Differentiating Chronic liver disease from other Diseases

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Differentiating Chronic Liver Disease from other Diseases

References

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Epidemiology and Demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Epidemiology and Demographics

References

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Risk Factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Risk Factors

  • Health care professionals who are exposed to body fluids and infected blood
  • Individuals who get multiple tattoos and body piercing
  • Certain prescription medications
  • Excessive alcohol use
  • Having high levels of fat in the blood
  • Sharing infected needle and syringes
  • Obesity
  • Having unprotected sex and multiple sex partners
  • Working with toxic chemicals without wearing safety clothes

References

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Natural History, Complications and Prognosis
Diagnosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Treatment

Medical Therapy | Surgery | Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case Studies

Case #1

Related Chapters


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