Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Chronic neutrophilic leukemia historical perspective
Introduction
Overview
Overview
Chronic neutrophilic leukemia(CNL) was first presented by Tuohy, in a case of splenomegaly and neutrophilic leukocytosis, in 1920. Although, It was named by Tanzer et al, in 1964. WHO introduced the criteria for the diagnosis of this disease as a myeloproliferative disorder in 2001. In 2013, CSF3R (colony stimulating factor 3 receptor) mutations was proposed that was found in the most CNL patients and made a huge change in diagnosis and treatment of this patient.
Historical Perspective
Historical Perspective
Discovery
- In 1920, Tuohy described the first case of CNL with severe splenomegaly and neutrophilic leukocytosis as a unique disease. However, it was named for the fist time as CNL by Tanzer et al, in 1964.[1][2]
- In 2001, WHO introduced the criteria for diagnosis CNL as a myeloproliferative disorder that was revised in 2016.[3]
- In 2013, CSF3R (colony stimulating factor 3 receptor) mutations was proposed that was found in the most CNL patients.[4]
References
References
- ↑ Tuohy, E. L. (1920). “A CASE OF SPLENOMEGALY WITH POLYMORPHONUCLEAR NEUTROPHIL HYPERLEUKOCYTOSIS”. The American Journal of the Medical Sciences. 160 (1): 18–24. doi:10.1097/00000441-192007000-00003. ISSN 0002-9629.
- ↑ Tanzer, J.; Harel, P.; Boiron, M.; Bernard, Jean (1964). “CYTOCHEMICAL AND CYTOGENETIC FINDINGS IN A CASE OF CHRONIC NEUTROPHILIC LEUKÆMIA OF MATURE CELL TYPE”. The Lancet. 283 (7329): 387–388. doi:10.1016/S0140-6736(64)92142-7. ISSN 0140-6736.
- ↑ Uppal, Guldeep; Gong, Jerald (2015). “Chronic neutrophilic leukaemia”. Journal of Clinical Pathology. 68 (9): 680–684. doi:10.1136/jclinpath-2015-203060. ISSN 0021-9746.
- ↑ Maxson, Julia E.; Gotlib, Jason; Pollyea, Daniel A.; Fleischman, Angela G.; Agarwal, Anupriya; Eide, Christopher A.; Bottomly, Daniel; Wilmot, Beth; McWeeney, Shannon K.; Tognon, Cristina E.; Pond, J. Blake; Collins, Robert H.; Goueli, Basem; Oh, Stephen T.; Deininger, Michael W.; Chang, Bill H.; Loriaux, Marc M.; Druker, Brian J.; Tyner, Jeffrey W. (2013). “Oncogenic CSF3R Mutations in Chronic Neutrophilic Leukemia and Atypical CML”. New England Journal of Medicine. 368 (19): 1781–1790. doi:10.1056/NEJMoa1214514. ISSN 0028-4793.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Homa Najafi, M.D.[2]; Grammar Reviewer: Natalie Harpenau, B.S.[3]