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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Chronic renal failure future or investigational therapies

Introduction

Emerging Therapies

Emerging Therapies

  • Primary, secondary, and tertiary prevention of CKD is increasingly possible because of genetic diagnoses. 
  • A recent study involving a small molecule Inaxaplin reverses the toxic gain-of-function effect of APOL1 high-risk variants, in patients with two APOL1 variants and biopsy-proven FSGS.
  • A mouse model showed that gene transfer of Pkd1 trans gene lead to re expression of polycystic 1 protein thereby markedly delayed cyst development, retarded cyst progression, and postponed kidney failure in Pkd
References

References