Churg-Strauss syndrome other diagnostic studies

Bronchoalveolar lavage, Pulmonary function tests and biopsy of lung, skin, kidney, muscle and nerve can be used to diagnose and differentiate eosinophilic granulomatosis with polyangiitis.

The following studies can be helpful in diagnosing eosinophilic granulomatosis with polyangiitis.^[1][2]

• Pulmonary function tests:
  • Spirometry findings are consistent with asthma.
    • Decreased total vital capacity
    • Decreased functional vital capacity
    • Decreased FEV1/FVC ratio
    • Decreased diffusion capacity
• Bronchoalveolar lavage:
  • Shows marked eosinophilia. Presence of marked eosinophilia on bronchoalveolar lavage is not specific for the diagnosis of eosinophilic granulomatosis with polyangiitis.
• Biopsy
  • Because of the multiple organ involvements, the biopsy should be obtained from any of the following organ sites:
    • Lung:
      • The gold standard in establishing a diagnosis for eosinophilic granulomatosis with polyangiitis is a lung biopsy. surgical or transbronchial biopsy can be performed.^[3]
    • Skin
    • Nerve
    • Kidney
    • Muscle
  • Biopsy findings may include eosinophilic infiltration, vasculitis of small and medium-sized vessels and granuloma formation.

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