Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Chymopapain
Introduction
Overview
Overview
Chymopapain (EC 3.4.22.6, chymopapain A, chymopapain B, chymopapain S, brand name Chymodiactin) is a proteolytic enzyme isolated from the latex of papaya (Carica papaya). It is a medication used to treat herniated lower lumbar discs in the spine.[1] Chymopapain injections are normally given under local, rather than general, anaesthesia. The dose for a single intervertebral disc is 2 to 4 nanokatals, with a maximum dose per patient of 8 nanokatals. The procedure is referred to as chemonucleolysis.
The sale and distribution of chymopapain was discontinued in the United States on January 27, 2003 after the company producing it decided to stop selling worldwide.[2][3]
Side effects
Side effects
Serious side effects from the use of chymopapain include anaphylaxis, paralysis of the legs, or death.[4]
References
References
External links
External links
- The MEROPS online database for peptidases and their inhibitors: C01.002
- Data sheet for Papain from BIOZYM
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]