Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Cirrhosis risk factors
Introduction
Overview
Overview
Lifestyle and genetic risk factors play an important role in the development of cirrhosis in patients. Chronic alcohol use, chronic hepatitis B and C infection and genetic diseases such as cystic fibrosis are also significant risk factors for the development of cirrhosis.
Risk Factors
Risk Factors
The risk factors of cirrhosis are as follows:
- Chronic alcohol abuse: regular moderate alcohol consumption is the most common cause of cirrhosis in the United States and other western countries[1]
- Chronic Hepatitis B and C viruses: most common cause of cirrhosis in Asian countries
- Autoimmune hepatitis
- Chronic blockage of the bile duct
- Wilson’s Disease
- hemochromatosis
- Cystic fibrosis
- Alpha l-antitrypsin deficiency
- Nonalcoholic fatty liver disease
- Prolonged exposure to drugs and toxins
- Age above 50 years [2]
- Male gender [3]
- Features of metabolic syndrome in Non Alcoholic Steato Heaptitis(NASH): [4][5]
References
References
- ↑ Bellentani S, Saccoccio G, Costa G, Tiribelli C, Manenti F, Sodde M, Saveria Crocè L, Sasso F, Pozzato G, Cristianini G, Brandi G (1997). “Drinking habits as cofactors of risk for alcohol induced liver damage. The Dionysos Study Group”. Gut. 41 (6): 845–50. PMC 1891602. PMID 9462221.
- ↑ Poynard T, Bedossa P, Opolon P (1997). “Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups”. Lancet. 349 (9055): 825–32. PMID 9121257.
- ↑ Bellentani S, Pozzato G, Saccoccio G, Crovatto M, Crocè LS, Mazzoran L, Masutti F, Cristianini G, Tiribelli C (1999). “Clinical course and risk factors of hepatitis C virus related liver disease in the general population: report from the Dionysos study”. Gut. 44 (6): 874–80. PMC 1727553. PMID 10323892.
- ↑ Clark JM (2006). “The epidemiology of nonalcoholic fatty liver disease in adults”. J. Clin. Gastroenterol. 40 Suppl 1: S5–10. doi:10.1097/01.mcg.0000168638.84840.ff. PMID 16540768.
- ↑ Farrell GC, Larter CZ (2006). “Nonalcoholic fatty liver disease: from steatosis to cirrhosis”. Hepatology. 43 (2 Suppl 1): S99–S112. doi:10.1002/hep.20973. PMID 16447287.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2] Sudarshana Datta, MD [3]