Combined injectable contraceptive

Template:BirthControl infobox Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Combined injectable contraceptive (CIC) monthly injection of progesterone and estradiol taken to inhibit fertility. Brand names include Cyclofem, Novafem, Mesigyna, Lunelle.

History

October 5, 2000, Pharmacia received FDA approval for Lunelle™ Monthly Contraceptive Injection.^[1]
April 2003, Pharmacia acquired by Pfizer (makers of Depo-provera).
October 2003, Lunelle was discontinued in the U.S.

Use and packaging

Administered by intramuscular injection into the deltoid, gluteus maximus, or anterior thigh.^[1] Ideally administered every 28 to 30 days, though demonstrated to be effective up to 33 days.^[1]

Side-effects

The most prominent side effects are menstrual irregularities during the first 3 to 6 months of use.^[1]

Formulations

Lunelle contains medroxyprogesterone acetate (MPA) 25 mg plus estradiol cypionate (E2C) 5 mg.^[1]
Cyclofem contains depomedroxy-progesterone acetate (DMPA) 25 mg and estradiol cypionate 5 mg.
Mesigyna contains norethisterone enanthate (NET EN) 50 mg and estradiol valerate 5 mg.
Deladroxate contains dihydroxy-progesterone acetophenide 150 mg and estradiol enanthate 10 mg.

Footnotes

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 “FDA Approves Combined Monthly Injectable Contraceptive”. Contraception Report. 12 (3). 2001.

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Template:WikiDoc Sources

[contrareportFDAAproveLunelle-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 “FDA Approves Combined Monthly Injectable Contraceptive”. Contraception Report. 12 (3). 2001.

[1]

Combined injectable contraceptive

History

Use and packaging

Side-effects

Formulations

See also

Footnotes

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