Symptoms in newborns may include:^{[1] [2]}

• Failure to gain weight or failure to thrive
• Fever
• Irritability
• Flat nasal bridge (saddle nose)
• Early rash – small blisters on the palms and soles
• Later rash – copper-colored, flat or bumpy rash on the face, palms, and soles
• Rash of the mouth, genitalia, and anus
• Watery discharge from the nose

Symptoms in older infants and young children may include:

• Bone pain
• Blindness
• Decreased hearing or deafness
• Joint swelling
• Refusal to move a painful arm or leg
• Scarring of the skin around the mouth, genitalia, and anus