In cor triatriatum, adminstration of effective medical therapy in a timely manner can serve as a supplementary, supportive measure prior to surgical therapy. Medical therapy measures should focus on addresses various complication complexes and preventing further complications from developing prior to surgery.

Medical therapy is primarily supportive to manage pulmonary venous congestion until surgical resection can be performed.

Commonly, medical therapy includes:

• Hemodynamic stabilization via manipulation of hypoxemia, pulmonary congestion and fluid overload
• Use of anticoagulants and anticoagulant prophylaxis to serve as a preventative measure in right-sided heart failure patients prone to deep vein thrombosis and pulmonary embolization
• Control and stablization of ventricular rate in patients with a support atrial fibrillation complex
• Use of medication to control fluid retention and the rate-control of arrhythmias

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