Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Cowden syndrome surgery
Introduction
Overview
Overview
Surgery is not the first-line treatment option for patients with cowden syndrome. Surgery is usually reserved for patients with gastrointestinal polyps, Dysplastic Gangliocytoma and facial papules.
Indications
Indications
- Surgery is not the first-line treatment option for patients with cowden syndrome. Surgery is usually reserved for patients with the following:
- Dysplastic Gangliocytoma:
- Keeping in mind about the potential effects of hydrocephalus like fatal herniation, resection of dysplastic gangliocytoma of the cerebellum should be considered.[1][2]
- Gastrointestinal polyps:
- Patients with cowden syndrome should consider resection of gastrointestinal polyps endoscopically which includes adenomatous polyps which are risk for developing colon cancer.[3][4]
- Endoscopic techniques like narrow band imaging should be considered for removing large polyps (≥1 cm).[5]
References
References
- ↑ Robinson, Shenandoah; Cohen, Alan R. (2006). “Cowden disease and Lhermitte–Duclos disease: an update”. Neurosurgical Focus. 20 (1): 1–6. doi:10.3171/foc.2006.20.1.7. ISSN 1092-0684.
- ↑ Shinagare, Atul B.; Patil, Nirupama K.; Sorte, S. Z. (2009). “Case 144: Dysplastic Cerebellar Gangliocytoma (Lhermitte-Duclos Disease)”. Radiology. 251 (1): 298–303. doi:10.1148/radiol.2511071390. ISSN 0033-8419.
- ↑ Levi Z, Baris HN, Kedar I, Niv Y, Geller A, Gal E, Gingold R, Morgenstern S, Baruch Y, Leach BH, Bronner MP, Eng C (November 2011). “Upper and Lower Gastrointestinal Findings in PTEN Mutation-Positive Cowden Syndrome Patients Participating in an Active Surveillance Program”. Clin Transl Gastroenterol. 2: e5. doi:10.1038/ctg.2011.4. PMC 3365666. PMID 23238744.
- ↑ Heald B, Mester J, Rybicki L, Orloff MS, Burke CA, Eng C (December 2010). “Frequent gastrointestinal polyps and colorectal adenocarcinomas in a prospective series of PTEN mutation carriers”. Gastroenterology. 139 (6): 1927–33. doi:10.1053/j.gastro.2010.06.061. PMC 3652614. PMID 20600018.
- ↑ Howe JR, Mitros FA, Summers RW (December 1998). “The risk of gastrointestinal carcinoma in familial juvenile polyposis”. Ann. Surg. Oncol. 5 (8): 751–6. PMID 9869523.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]